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Zonisamide

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Indications

Zonisamide is indicated to control partial seizures in adults with epilepsy.
Zonisamide is indicated with other medications to prevent and control seizures (epilepsy).

They need to know if you have any of these conditions:
- an unusual or allergic reaction to Zonisamide, sulfa drugs, other medicines, foods, dyes, or preservatives;
- breast-feeding;
- dehydrated;
- diarrhea;
- ketogenic diet;
- kidney disease;
- liver disease;
- lung disease;
- pregnant or trying to get pregnant;
- suicidal thoughts, plans, or attempt; a previous suicide attempt by you or a family member;

Contraindications

Zonisamide is contraindicated if you have any of the following conditions:
- if you are allergic to Zonisamide;
- if you have a special diet (ketogenic diet);
- if you have any other allergies;
- if you have kidney disease (such as kidney stones);
- if you have liver disease;
- if you have long-term diarrhea;
- if you have lung/breathing problems;
- if you have mental/mood problems (such as depression, psychosis);
- if you have metabolic imbalance (metabolic acidosis);

Interactions

Do not take Zonisamide with any of the following drugs:
- Alcohol;
- Alprazolam;
- Antihistamines (such as cetirizine;
- barbiturates like phenobarbital;
- carbamazepine;
- Carbonic anhydrase inhibitors (acetazolamide);
- Diazepam;
- Diphenhydramine);
- Drugs for sleep or anxiety;
- Medications to treat seizures;
- Muscle relaxants;
- Narcotic pain relievers (codeine);
- Phenobarbital;
- phenytoin;
- Primidone;
- Rifamycins (rifabutin);
- St John's wort;
- Zolpidem;

Side Effects

Zonisamide side effects that you should report to your health care professional or doctor as soon as possible:
- allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue;
- Change in the amount of urine;
- Dark/bloody urine;
- decreased sweating or a rise in body temperature, especially in patients under 17 years old;
- Decreased sweating;
- depression;
- Diarrhea;
- difficulty breathing or tightening of the throat;
- Dizziness;
- Double vision;
- Drowsiness;
- Easy bruising/bleeding;
- Experience depression;
- Fainting;
- Fast/irregular heartbeat;
- feeling faint or lightheaded, falls;
- fever, sore throat, sores in your mouth, or bruising easily;
- hallucination, loss of contact with reality;
- headache;
- irregular heartbeat;
- Itching/swelling (especially of the face/tongue/throat);
- Lack of coordination;
- loss of appetite;
- Mental/mood problems;
- nausea;
- Numb/tingling skin;
- Persistent sore throat);
- Rapid breathing;
- Rash;
- redness, blistering, peeling or loosening of the skin, including inside the mouth;
- Severe dizziness;
- severe drowsiness, difficulty concentrating, or coordination problems;
- Severe stomach/abdominal pain;
- Signs of depression;
- Signs of infection (such as fever;
- speech or language problems;
- Speech problems;
- sudden back pain, abdominal pain, pain when urinating, bloody or dark urine;
- Suicidal thoughts/attempts;
- Tiredness;
- Trouble breathing;
- Trouble sleeping;
- Unusual eye movements (nystagmus);
- Unusual tiredness;
- unusually tired;
- vomiting;
- worsening of mood, thoughts or actions of suicide or dying;
- Yellowing eyes/skin;

Overdose

Reported Zonisamide overdose symptoms are:
- Severe dizziness;
- Slow/shallow breathing;
- Loss of consciousness;