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Ziprasidone

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Indications

Ziprasidone can make you feel less nervous and improve your concentration.
Ziprasidone helps you to think more clearly and take a more active part in everyday life.
Ziprasidone is a psychiatric medication (anti-psychotic type) that works by helping to restore the balance of certain natural substances (neurotransmitters) in the brain.
Ziprasidone is indicated after other medications have not been effective.
Ziprasidone is indicated to treat certain mental/mood disorders (schizophrenia or manic/mixed episodes associated with bipolar disorder).
Ziprasidone is indicated to treat schizophrenia and bipolar disorder, also known as manic-depression.

Contraindications

Ziprasidone is contraindicated if you have any of the following conditions:
- an unusual or allergic reaction to Ziprasidone, other medicines, foods, dyes, or preservatives;
- breast-feeding;
- dementia;
- diabetes or high blood sugar;
- heart disease, including heart failure;
- irregular heartbeat;
- liver disease;
- low potassium level in the blood;
- Parkinson's disease or other movement disorders;
- pregnant or trying to get pregnant;
- previous heart attack or stroke;
- suicidal thoughts, plans, or attempt by you or a family member;
- if you are allergic to Ziprasidone;
- if you have Alzheimer's disease;
- if you have any other allergies;
- if you have aspiration pneumonia;
- if you have certain heart problems (recent heart attack, untreated heart failure);
- if you have certain medical conditions;
- if you have diabetes;
- if you have heart problems (coronary artery disease, irregular heartbeat, low blood pressure);
- if you have liver disease;
- if you have low white blood cell count;
- if you have nervous system problems (stroke, seizures, NMS);
- if you have obesity;
- if you have severe dizziness/fainting;
- if you have swallowing problems;

Interactions

Do not take Ziprasidone with any of the following drugs:
- alfuzosin;
- Amantadine;
- Amiodarone;
- Antifungals;
- Antimuscarinics (scopolamine);
- arsenic trioxide;
- Beta blockers;
- Bromocriptine;
- Bupropion;
- Calcium channel blockers;
- Carbamazepine;
- certain antidepressants;
- Certain anti-seizure medications;
- certain macrolide antibiotics like clarithromycin, erythromycin, telithromycin, and troleandomycin;
- certain quinolone antibiotics like gatifloxacin, grepafloxacin, levofloxacin, moxifloxacin, and sparfloxacin;
- chloroquine;
- cisapride;
- clozapine;
- diuretics;
- Dofetilide;
- dolasetron;
- Dopamine agonists;
- droperidol;
- Drugs affecting liver enzymes that remove Ziprasidone from your body;
- Drugs for high blood pressure;
- Erythromycin;
- halofantrine;
- haloperidol;
- Isoniazid (INH);
- Ketoconazole;
- Levodopa;
- levomethadyl;
- Macrolide antibiotics (erythromycin);
- Macrolide antibiotics;
- medicines for fungal infections like fluconazole, itraconazole, ketoconazole, voriconazole;
- medicines for Parkinson's disease;
- medicines for treating heart-rhythm problems like amiodarone, dofetilide, flecainide, procainamide, quinidine, and sotalol;
- methadone;
- palonosetron;
- pentamidine;
- Phenothiazines (chlorpromazine);
- phenothiazines like chlorpromazine, mesoridazine and thioridazine;
- Pimozide;
- probucol;
- Procainamide;
- propafenone;
- Quinidine;
- Rifampin;
- Rifamycins;
- risperidone;
- sertindole;
- Sibutramine;
- some medications for high blood pressure;
- Sotalol;
- St John's wort;
- stimulants like amphetamine, dextroamphetamine;
- tacrolimus;
- Theophylline;
- Tricyclic antidepressants (amoxapine);
- vardenafil;

Side Effects

Ziprasidone side effects that you should report to your health care professional or doctor as soon as possible:
- Agitation;
- Anxiety;
- change in emotion or behavior such as feeling depressed, angry, or anxious;
- chest pain;
- Confusion;
- constipation;
- Cough;
- Depression;
- difficulty breathing;
- difficulty swallowing;
- Difficulty walking;
- Dizziness;
- drowsiness;
- excessive thirst and/or hunger;
- Fainting;
- Fast heartbeat;
- fast or irregular heartbeat or palpitations;
- Feelings of restlessness;
- fever or chills, sore throat;
- Fever;
- frequently needing to urinate;
- Hallucinations;
- headache;
- inability to control muscle movements in the face, hands, arms, or legs;
- Increased sweating;
- Jaw/left arm pain;
- loss of balance or difficulty walking;
- Loss of coordination;
- Mask-like facial expression (pseudoparkinsonism);
- Mental/mood changes;
- Muscle spasm/stiffness;
- Muscle stiffness;
- nausea or vomiting;
- Nausea;
- Numbness/tingling;
- Persistent sore throat;
- prolonged erection;
- Runny nose;
- Seizures;
- Severe dizziness;
- Severe nausea/vomiting/diarrhea;
- Severe/persistent dizziness;
- Shakiness (tremors);
- Signs of infection;
- skin rash or hives;
- Slow/fast/irregular heartbeat;
- stiff muscles or jaw;
- Suicidal thoughts;
- tremor;
- Trouble swallowing;
- Twitchy muscles;
- uncontrollable movements or spasms of the face, tongue or mouth;
- Unexplained fever;
- Unusual restlessness;
- upset stomach;
- Vision problems;
- Vomiting;
- weakness or loss of strength;
- Weakness;

Overdose

Reported Ziprasidone overdose symptoms are:
- Fast/pounding heartbeat with headache;
- Slurred speech;
- Uncontrolled movements (tremor);