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Adalimumab

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Indications

Adalimumab slows the progression (destruction of the joints) and improves physical function (in adults) in moderate to severe rheumatoid arthritis.
Adalimumab is indicated after one or more other drugs that slow the destruction of the joints (referred to as disease modifying, anti-rheumatic drugs or DMARDs) have failed.
Adalimumab is indicated for reducing the signs and symptoms of rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and Crohn's disease.
Adalimumab is indicated in cases that are moderate to severe and/or keep coming back.
Adalimumab is indicated similarly (alone or in combination with DMARDS) for the treatment of ankylosing spondylitis, psoriatic arthritis,and Crohn's disease.
Adalimumab is indicated to reduce pain and swelling due to certain types of arthritis (rheumatoid, psoriatic, and ankylosing spondylitis).
Adalimumab is indicated to treat a bowel condition called Crohn's disease.
Adalimumab is indicated to treat Crohn's disease and plaque psoriasis.
Adalimumab is indicated to treat psoriasis (plaque-type).
Adalimumab is indicated to treat several types of arthritis.
Adalimumab works by blocking a protein (tumor necrosis factor or TNF) found in the body's immune system that causes joint swelling and damage.
Early treatment of rheumatoid arthritis with more aggressive therapy, including this type of medication (TNF blockers), helps to reduce further joint damage and preserve joint function.
In arthritis, Adalimumab can be used alone or in combination with methotrexate or other DMARDs.

Contraindications

Adalimumab is contraindicated if you have any of the following conditions:
- an unusual reaction to Adalimumab, other medicines, mannitol, latex, rubber, foods, dyes, or preservatives;
- breast-feeding;
- diabetes;
- heart disease;
- hepatitis B or history of hepatitis B infection;
- immune system problems;
- infection or history of infections;
- multiple sclerosis;
- pregnant or trying to get pregnant;
- recently received or scheduled to receive a vaccine;
- scheduled to have surgery;
- tuberculosis, a positive skin test for tuberculosis or have recently been in close contact with someone who has tuberculosis;
- if you are allergic to Adalimumab;
- if you are allergic to natural rubber/latex;
- if you have a certain type of heart disease (congestive heart failure);
- if you have an active infection;
- if you have any other allergies;
- if you have certain brain/spinal cord disorders (demyelinating disorders such as multiple sclerosis);
- if you have certain fungal infection (histoplasmosis);
- if you have decreased bone marrow function;
- if you have hepatitis B infection;
- if you have history of cancer (lymphoma);
- if you have lupus;
- if you have recurrent infections;
- if you have scheduled surgery;
- if you have seizures;
- if you have TB infection;

Interactions

Do not take Adalimumab with any of the following drugs:
- Abatacept;
- abatacept;
- Anakinra;
- Cyclosporine;
- Drugs that suppress the immune system;
- Etanercept;
- infliximab;
- Leflunomide;
- Live vaccines;
- live virus vaccines;
- Methotrexate;
- Other arthritis drugs;
- Other TNF-blockers;
- Prednisone;
- rilonacept;
- vaccines;

Side Effects

Adalimumab side effects that you should report to your health care professional or doctor as soon as possible:
- allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue;
- Blood in the stools;
- breathing problems;
- Butterfly-shaped rash on the nose and cheeks;
- changes in vision;
- Chest pain;
- Chills;
- Dark urine;
- Easy bruising or bleeding;
- Extreme fatigue;
- Fast/irregular/pounding heartbeat;
- fever, chills, or any other sign of infection;
- Fever;
- Headache;
- Itching at the site of injection;
- Itching/swelling (especially of the face/tongue/throat);
- Itching;
- Joint pain;
- Leg pain or swelling;
- Mental/mood changes;
- Nausea;
- Night sweats;
- Numbness or tingling of the hands or feet;
- numbness or tingling;
- Pain;
- Painful or frequent urination;
- Persistent cough;
- Persistent sore throat;
- Rash;
- red, scaly patches or raised bumps on the skin;
- redness, itching, swelling, or bruising at site where injected;
- Redness;
- Seizures;
- Severe dizziness;
- Severe headache;
- Stomach pain;
- Stomach upset;
- Swelling at the injection site;
- swelling of the ankles;
- Swelling;
- swollen lymph nodes in the neck, underarm, or groin areas;
- Trouble breathing;
- Unexplained muscle weakness;
- unexplained weight loss;
- Unsteadiness;
- unusual bleeding or bruising;
- Unusual vaginal discharge;
- unusually weak or tired;
- Vision changes;
- White patches in the mouth (oral thrush);
- Yellowing eyes and skin;

Form

Glass vial : 40 mg (0.8 ml)
Prefilled glass syringe: 40 mg (0.8 ml);

Dosage

Adalimumab is injected under the skin.
The recommended dose for adults is 40 mg every other week, but some patients may need weekly administration.